A tyrosinase inhibitor
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Kojic Acid

Item No. 22712

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
CAS Number
501-30-4
Synonyms
  • NSC 1942
Molecular Formula
C6H6O4
Formula Weight
142.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 16 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
218, 272 nm
SMILES
OC1=COC(CO)=CC1=O
InChi Code
InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
InChi Key
BEJNERDRQOWKJM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $49

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    Cayman Chemical
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    Product Description

    Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 µM for mushroom tyrosinase.1 It decreases growth of Leishmania parasites in vitro and in vivo, and it protects mice from damage induced by gamma irradiation.2,3 Kojic acid has been used as a food additive to prevent enzymatic browning.4 Formulations containing kojic acid are used in the treatment of hyperpigmentation disorders.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, Y.S., Park, J.H., Kim, M.H., et al. Synthesis of tyrosinase inhibitory kojic acid derivative. Arch. Pharm. (Weinheim) 339(3), 111-114 (2006).

    2. Rodrigues, A.P., Farias, L.H., Carvalho, A.S., et al. A novel function for kojic acid, a secondary metabolite from Aspergillus fungi, as antileishmanial agent. PLoS One 9(3), e91259 (2014).

    3. Wang, K., Liu, C., Di, C.-J., et al. Kojic acid protects C57BL/6 mice from gamma-irradiation induced damage. Asian Pac. J. Cancer Prev. 15(1), 291-297 (2014).

    4. Burdock, G.A., Soni, M.G., and Carabin, I.G. Evaluation of health aspects of kojic acid in food. Regul. Toxicol. Pharmacol. 33(1), 80-101 (2001).

    5. Kim, Y.M., Yun, J., Lee, C.K., et al. Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of action. The Journal of Biological Chemisty 277(18), 16340-16344 (2002).