A PORCN inhibitor
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IWP-12

Item No. 22729

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
CAS Number
688353-45-9
Synonyms
  • Inhibitor of Wnt Production-12
Molecular Formula
C18H18N4O2S3
Formula Weight
418.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 2 mg/ml
λmax
278, 302, 335 nm
SMILES
O=C(CSC(N1C)=NC2=C(SC(C)C2)C1=O)NC3=NC4=C(C=C(C)C=C4)S3
InChi Code
InChI=1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23)
InChi Key
RBFDSBJDWZOTGR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $148

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    10 mg

    $227

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    25 mg

    $520

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    Product Description

    IWP-12 is a small molecule inhibitor of porcupine (PORCN), which is an acyltransferase that palmitoylates and activates Wnt proteins.1 IWP-12 inhibits cell-autonomous Wnt signaling with an IC50 value of 15 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, X., Moon, J., Dodge, M.E., et al. The development of highly potent inhibitors for porcupine. J. Med. Chem. 56(6), 2700-2704 (2013).