A colorimetric dye for the detection of fluoride ions
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Alizarin-3-methyliminodiacetic Acid

Item No. 22890

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(carboxymethyl)-N-[(9,10-dihydro-3,4-dihydroxy-9,10-dioxo-2-anthracenyl)methyl]-glycine
CAS Number
3952-78-1
Synonyms
  • Alizarin Complexone
  • Alizarin Fluorine Blue
  • NSC 293056
Molecular Formula
C19H15NO8
Formula Weight
385.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml
λmax
249, 429 nm
SMILES
O=C1C2=C(C(O)=C(O)C(CN(CC(O)=O)CC(O)=O)=C2)C(C3=C1C=CC=C3)=O
InChi Code
InChI=1S/C19H15NO8/c21-13(22)7-20(8-14(23)24)6-9-5-12-15(19(28)16(9)25)18(27)11-4-2-1-3-10(11)17(12)26/h1-5,25,28H,6-8H2,(H,21,22)(H,23,24)
InChi Key
PWIGYBONXWGOQE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    1 g

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    5 g

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    Product Description

    Alizarin-3-methyliminodiacetic acid is a colorimetric dye for the detection of fluoride ions.1 It reacts with fluoride to form a lilac-blue complex which can be quantified colorimetrically at 620 nm to determine fluoride concentration. Alizarin-3-methyliminodiacetic acid has been used to visualize fluoride deposition and bone mineralization during development in medaka larvae.2 It is also an inhibitor of inducible nitric oxide synthase (iNOS; IC50 = 35 nM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, X.-y., and Long, X.-l. Continuous-flow-injection analysis of fluoride in vegetables. Guandong Nongye Kexue 40(13), 104-105 (2013).

    2. Yu, T., Witten, P.E., Huysseune, A., et al. Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Dis. Model Mech. 9(2), 155-163 (2016).

    3. Gálvez-Llompart, N., Recico, M.C., García-Domenech, R., et al. Molecular topology: A strategy to identify novel compounds against ulcerative colitis. Mol. Divers. 21(1), 219-234 (2017).