An internal standard for the quantification of raloxifene
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Raloxifene-d4 (hydrochloride)

Item No. 22900

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy-1,1,2,2-d4)phenyl)methanone hydrochloride
CAS Number
1188263-47-9
Molecular Formula
C28H23D4NO4S • HCl
Formula Weight
514.1
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
OC1=CC=C(C(C(C2=CC=C(OC([2H])([2H])C([2H])([2H])N3CCCCC3)C=C2)=O)=C(C4=CC=C(O)C=C4)S5)C5=C1.Cl
InChi Code
InChI=1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H/i16D2,17D2;
InChi Key
BKXVVCILCIUCLG-ZBLPOJTCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $115

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    1 mg

    $213

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    5 mg

    $944

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    Product Description

    Raloxifene-d4 is intended for use as an internal standard for the quantification of raloxifene (Item No. 10011620) by GC- or LC-MS. Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits estrogenic activity in bone cells without stimulating breast or uterine tissues.1 Raloxifene guards endothelial cells obtained from rat aortic rings against oxidative insult (1 µM) and lowers serum cholesterol in ovariectomized rodents (ED50 = 0.2 mg/kg).2,1 Formulations containing raloxifene have been shown to reduce bone resorption and promote bone formation in post-menopausal women.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Black, L.J., Sato, M., Rowley, E.R., et al. Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J. Clin. Invest. 93(1), 63-69 (1994).

    2. Wong, C.M., Yung, L.M., Leung, F.P., et al. Raloxifene protects endothelial cell function against oxidative stress. Br. J. Pharmac. 155(3), 326-334 (2008).

    3. Özmen, B., Kirmaz, C., Aydin, K., et al. Influence of the selective oestrogen receptor modulator (raloxifene hydrochloride) on IL-6, TNF-α, TGF-ß1 and bone turnover markers in the treatment of postmenopausal osteoporosis. Eur. Cyto. Netw. 18(3), 148-153 (2007).