A positive allosteric modulator of nAChRs
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Morantel (tartrate)

Item No. 22902

Technical Information
Formal Name
1,4,5,6-tetrahydro-1-methyl-2-[(2E)-2-(3-methyl-2-thienyl)ethenyl]-pyrimidine, 2R,3R-dihydroxybutanedioate
CAS Number
26155-31-7
Synonyms
  • CP 12,009-18
  • UK 2964-18
Molecular Formula
C12H16N2S • C4H6O6
Formula Weight
Purity
≥98%
Formulation
A crystalline solid
DMF: 33 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
238, 323 nm
SMILES
CN1CCCN=C1/C=C/C2=C(C)C=CS2.OC([C@H](O)[C@@H](O)C(O)=O)=O
InChi Code
InChI=1S/C12H16N2S.C4H6O6/c1-10-6-9-15-11(10)4-5-12-13-7-3-8-14(12)2;5-1(3(7)8)2(6)4(9)10/h4-6,9H,3,7-8H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/b5-4+;/t;1-,2-/m.1/s1
InChi Key
GGXQONWGCAQGNA-UUSVNAAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Morantel is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs).1 It enhances channel gating of the α3β2 nAChR subtype by binding to non-canonical sites.2 Formulations containing morantel are used to treat nematode infections in livestock.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, T.Y., Smith, C.M., Sine, S.M., et alMorantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors. Mol. Pharmacol. 74(2), 466-475 (2008).

    2. Seo, S., Henry, J.T., Lewis, A.H., et alThe positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors. J. Neurosci. 29(27), 8734-8742 (2009).

    3. McKellar, Q.A., Scott, E.W., Baxter, P., et alPharmacodynamics, pharmacokinetics and faecal persistence of morantel in cattle and goats. J. Vet. Pharmacol. Ther. 16(1), 87-92 (1993).