A chemiluminescence enhancer
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PTZ-343

Item No. 22908

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10H-phenothiazine-10-propanesulfonic acid, monosodium salt
CAS Number
101199-38-6
Molecular Formula
C15H14NO3S2 • Na
Formula Weight
343.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
255, 312 nm
SMILES
[O-]S(CCCN1C2=C(C=CC=C2)SC3=CC=CC=C31)(=O)=O.[Na+]
InChi Code
InChI=1S/C15H15NO3S2.Na/c17-21(18,19)11-5-10-16-12-6-1-3-8-14(12)20-15-9-4-2-7-13(15)16;/h1-4,6-9H,5,10-11H2,(H,17,18,19);/q;+1/p-1
InChi Key
VKGYKXFNSKEHED-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $69

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    100 mg

    $127

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    250 mg

    $297

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    500 mg

    $427

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    Product Description

    PTZ-343 is a water-soluble enhancer of luminol (Item No. 16803) chemiluminescent peroxidation catalyzed by horseradish peroxidase (HRP).1 It acts as an electron transfer mediator, reacting with HRP-II to release HRP and a PTZ-343 radical, which oxidizes luminol anions to induce light emission. HRP-induced chemiluminescent light emission increases by >800% in the presence of PTZ-343. It also enhances soybean peroxidase-induced chemiluminescence, increasing sensitivity and lowering the detection limit from 1.1 to 0.18 pM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Marzocchi, E., Grilli, S., Della Ciana, L., et al. Chemiluminescent detection systems of horseradish peroxidase employing nucleophilic acylation catalysts. Anal. Biochem. 377(2), 189-194 (2008).

    2. Vdovenko, M.M., Della Ciana, L., and Sakharov, I.Y. 3-(100-Phenothiazinyl)propane-1-sulfonate is a potent enhancer of soybean peroxidase-induced chemiluminescence. Anal. Biochem. 392(1), 54-58 (2009).