A selective antagonist of σ1 receptors
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BD 1047 (hydrobromide)

Item No. 22928

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-[2-(3,4-dichlorophenyl)ethyl]-N1,N2,N2-trimethyl-1,2-ethanediamine, dihydrobromide
CAS Number
138356-21-5
Molecular Formula
C13H20Cl2N2 • 2HBr
Formula Weight
437.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
ClC1=C(Cl)C=CC(CCN(C)CCN(C)C)=C1.Br.Br
InChi Code
InChI=1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H
InChi Key
WOALTFHGLDVJHK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $75

    Add

    10 mg

    $134

    Add

    25 mg

    $259

    Add
    Product Description

    BD 1047 is a selective antagonist of sigma-1 (σ1) receptors (Ki = 0.9 nM in a radioligand binding assay).1 It is selective for σ1 receptors with binding affinity values greater than 10,000 nM for human recombinant dopamine, opioid, PCP, and serotonin receptors in vitro. In vivo, pretreatment with BD 1047 protects against convulsions and lethality induced by cocaine (Item Nos. 16186 | ISO60176) and reduces cocaine-induced locomotor activity. It reduces dystonias induced by the σ receptor agonists haloperidol (Item No. 12014) and di-o-tolylguanidine (DTG) in rats in a dose-dependent manner.2 In vivo administration of BD 1047 also attenuates mechanical allodynia and microglial activation in a rat model of bone cancer pain.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCracken, K.A., Bowen, W.D., de Costa, B.R., et al. Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity. Eur. J. Pharmacol. 370(3), 225-232 (1999).

    2. Matsumoto, R.R., Bowen, W.D., Tom, V.A., et al. Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism. Eur. J. Pharmacol. 280(3), 301-310 (1995).

    3. Zhu, S., Wang, C., Han, Y., et al. Sigma-1 receptor antagonist BD1047 reduces mechanical allodynia in a rat model of bone cancer pain through the inhibition of spinal NR1 phosphorylation and microglia activation. mediators Inflamm. 2015, 265056 (2015).