A Syk inhibitor
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R112

Item No. 22929

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-phenol
CAS Number
575474-82-7
Molecular Formula
C16H13FN4O2
Formula Weight
312.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
λmax
271, 321 nm
SMILES
OC1=CC=CC(NC2=NC=C(F)C(NC3=CC(O)=CC=C3)=N2)=C1
InChi Code
InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21)
InChi Key
TVKGTSHBQZEFEE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $28

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    5 mg

    $97

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    10 mg

    $165

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    25 mg

    $310

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    Product Description

    R112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM).1 It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; Item No. 20210) and decreases cytokine levels in cultured human mast cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rossi, A.B., Herlaar, E., Braselmann, S., et al. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J. Allergy Clin. Immunol. 118(3), 749-755 (2006).