An antibiotic with antimycobacterial activity
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BTZ043

Item No. 22930

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
CAS Number
1161233-85-7
Molecular Formula
C17H16F3N3O5S
Formula Weight
431.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
211, 245, 342 nm
SMILES
O=C1N=C(N2CCC3(OC[C@H](C)O3)CC2)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C41
InChi Code
InChI=1S/C17H16F3N3O5S/c1-9-8-27-16(28-9)2-4-22(5-3-16)15-21-14(24)11-6-10(17(18,19)20)7-12(23(25)26)13(11)29-15/h6-7,9H,2-5,8H2,1H3/t9-/m0/s1
InChi Key
GTUIRORNXIOHQR-VIFPVBQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    BTZ043 is an antibiotic with antimycobacterial activity.1 It targets mycobacterial cell wall synthesis by inhibiting DprE1, which, in conjunction with DprE2, catalyzes the epimerization of decaprenylphosphoryl ribose to decaprenylphosphoryl arabinose. BTZ043 is active against various Mycobacterium species in vitro, including M. smegmatis, M. bovis, and M. tuberculosis (MICs = 4, 2, and 1 ng/ml, respectively), as well as the actinobacterium N. brasiliensis (MIC50 = 0.125 μg/ml).1,2 It is also active against M. tuberculosis in RAW 264.7 murine macrophages (MIC = <10 ng/ml).1 BTZ043 (37.5 or 300 mg/kg for four weeks) reduces the number of viable M. tuberculosis cells in lung and spleen in a mouse model of chronic tuberculosis infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Makarov, V., Manina, G., Mikusova, K., et al. Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science 324(5928), 801-804 (2009).

    2. Vera-Cabrera, L., Campos-Rivera, M.P., Gonzalez-Martinez, N.A., et al. In vitro activities of the new antitubercular agents PA-824 and BTZ043 against Nocardia brasiliensis. Antimicrob. Agents Chemother. 56(7), 3984-3985 (2012).