An orexin 2 receptor agonist
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Orexin 2 Receptor Agonist

Item No. 22937

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4'-methoxy-N,N-dimethyl-3'-[[[3-[[2-[(3-methylbenzoyl)amino]ethyl]amino]phenyl]amino]sulfonyl]-[1,1'-biphenyl]-3-carboxamide
CAS Number
1796565-52-0
Synonyms
  • OX2R
Molecular Formula
C32H34N4O5S
Formula Weight
586.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 20 mg/ml
λmax
210, 252 nm
SMILES
O=S(NC1=CC(NCCNC(C2=CC=CC(C)=C2)=O)=CC=C1)(C3=C(OC)C=CC(C4=CC(C(N(C)C)=O)=CC=C4)=C3)=O
InChi Code
InChI=1S/C32H34N4O5S/c1-22-8-5-10-25(18-22)31(37)34-17-16-33-27-12-7-13-28(21-27)35-42(39,40)30-20-24(14-15-29(30)41-4)23-9-6-11-26(19-23)32(38)36(2)3/h5-15,18-21,33,35H,16-17H2,1-4H3,(H,34,37)
InChi Key
RHLMXWCISNJNDH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $171

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    10 mg

    $319

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    25 mg

    $707

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    Product Description

    Orexin 2 receptor agonist is an agonist of the orexin 2 receptor (OX2R) with an EC50 value of 23 nM in a calcium influx assay.1 It is 70-fold selective for OX2R over OX1R (EC50 = 1,616 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nagahara, T., Saitoh, T., Kutsumura, N., et al. Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J. Med. Chem. 58(20), 7931-7937 (2015).