A DNA ligase inhibitor
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L67

Item No. 22941

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3,5-dibromo-4-methylphenyl)-glycine, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide
CAS Number
325970-71-6
Molecular Formula
C16H14Br2N4O4
Formula Weight
486.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
λmax
217, 280 nm
SMILES
OC1=CC=C([N+]([O-])=O)C=C1/C=N/NC(CNC2=CC(Br)=C(C)C(Br)=C2)=O
InChi Code
InChI=1S/C16H14Br2N4O4/c1-9-13(17)5-11(6-14(9)18)19-8-16(24)21-20-7-10-4-12(22(25)26)2-3-15(10)23/h2-7,19,23H,8H2,1H3,(H,21,24)/b20-7+
InChi Key
KFEPVFJQVOMODD-IFRROFPPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

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    25 mg

    $477

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    50 mg

    $794

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    Cayman Chemical
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    Product Description

    L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 µM for human DNA ligase I and human ligase IIIβ).1 It blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells.2 It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, X., Zhong, S., Zhu, X., et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68(9), 3169-3177 (2008).

    2. Sallmyr, A., Matsumoto, Y., Roginskaya, V., et al. Inhibiting mitochondrial DNA ligase IIIα activates caspase 1-dependent apoptosis in cancer cells. Cancer Res. 76(18), 5431-5441 (2016).