An inhibitor of tubulin polymerization
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Cycle
G2/M
Multidrug Resistance

D-64131

Item No. 22944

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5-methoxy-1H-indol-2-yl)phenyl-methanone
CAS Number
74588-78-6
Molecular Formula
C16H13NO2
Formula Weight
251.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS (pH 7) (1:10): 0.16 mg/mlDMSO: 25 mg/ml
λmax
324 nm
SMILES
COC1=CC=C2C(C=C(C(C3=CC=CC=C3)=O)N2)=C1
InChi Code
InChI=1S/C16H13NO2/c1-19-13-7-8-14-12(9-13)10-15(17-14)16(18)11-5-3-2-4-6-11/h2-10,17H,1H3
InChi Key
ICMIJSRDISNKOC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $193

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    25 mg

    $424

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    50 mg

    $635

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    Cayman Chemical
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    Product Description

    D-64131 is an antimitotic agent that inhibits polymerization of microtubules with an IC50 value of 0.53 µM in a radioligand binding assay using purified tubules from bovine brain.1 It arrests the cell cycle at the G2/M transition (IC50 = 92 nM) and is preferentially cytotoxic to cycling cells. It has antiproliferative activity in cancer cell lines derived from various tissues and organs (IC50s = 24-144 nM) and in cell lines resistant to other tubulin inhibitors (IC50s = 20-77 nM). D-64131 (200 and 400 mg/kg) is also efficacious in reducing tumor growth in a mouse xenograft model of human amelanoic melanoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beckers, T., Reissmann, T., Schmidt, M., et al. 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 62(11), 3113-3119 (2002).