An Mcl-1 inhibitor
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3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid

Item No. 22948

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,6-dichloro-benzo[b]thiophene-2-carboxylic acid
CAS Number
34576-94-8
Molecular Formula
C9H4Cl2O2S
Formula Weight
247.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
239, 251, 296 nm
SMILES
ClC1=CC=C(C(Cl)=C(C(O)=O)S2)C2=C1
InChi Code
InChI=1S/C9H4Cl2O2S/c10-4-1-2-5-6(3-4)14-8(7(5)11)9(12)13/h1-3H,(H,12,13)
InChi Key
AAHPIJMQJAZYTM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $36

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    250 mg

    $70

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    500 mg

    $120

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    Product Description

    3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1.1 It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Friberg, A., Vigil, D., Zhao, B., et al. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J. Med. Chem. 56(1), 15-30 (2013).

    2. Cheng, K., Wang, X., and Yin, H. Small-molecule inhibitors of the TLR3/dsRNA complex. J. Am. Chem. Soc. 133(11), 3764-3767 (2011).

    3. Katane, M., Osaka, N., Matsuda, S., et al. Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. J. Med. Chem. 56(5), 1894-1907 (2013).