A selective inhibitor of Epac2
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HJC0350

Item No. 22949

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
CAS Number
885434-70-8
Molecular Formula
C15H19NO2S
Formula Weight
277.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 10 mg/ml
λmax
204 nm
SMILES
CC1=C(S(N2C=C(C)C=C2C)(=O)=O)C(C)=CC(C)=C1
InChi Code
InChI=1S/C15H19NO2S/c1-10-6-12(3)15(13(4)7-10)19(17,18)16-9-11(2)8-14(16)5/h6-9H,1-5H3
InChi Key
AFZWZVLPIMHLSE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $153

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    25 mg

    $336

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    Product Description

    HJC0350 is a selective inhibitor of exchange protein directly activated by cAMP 2 (Epac2) with an IC50 value of 300 nM for competition with 8-NBD-cAMP binding.1 It inhibits Epac2 guanine nucleotide exchange activity but does not inhibit Epac1-mediated Rap1-GDP exchange or cAMP-mediated protein kinase A (PKA) activation in vitro, indicating it is selective for Epac2 at a concentration of 25 μM. HJC0350 also blocks stimulation of Epac2, but not Epac1, by 007-AM in HEK293 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, H., Tsalkova, T., Chepurny, O.G., et al. Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J. Med. Chem. 56(3), 952-962 (2013).