A Kv7 channel activator
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ICA 069673

Item No. 22995

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-benzamide
CAS Number
582323-16-8
Molecular Formula
C11H6ClF2N3O
Formula Weight
269.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
267 nm
SMILES
ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1
InChi Code
InChI=1S/C11H6ClF2N3O/c12-11-15-4-7(5-16-11)17-10(18)6-1-2-8(13)9(14)3-6/h1-5H,(H,17,18)
InChi Key
IIBSHMFXVWTQSJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $105

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    10 mg

    $184

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    25 mg

    $400

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    50 mg

    $796

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    Product Description

    ICA 069673 is a heteromeric Kv7 channel activator.1,2 It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner.2 ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM).1 Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively).1 Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Amato, G., Roeloffs, R., Rigdon, G.C., et al. N-Pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med. Chem. Lett. 2(6), 481-484 (2011).

    2. Brueggemann, L.I., Haick, J.M., Cribbs, L.L., et al. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol. Pharmacol. 86(3), 330-341 (2014).