An α1-adrenergic receptor agonist
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Tetrahydrozoline (hydrochloride)

Item No. 23004

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole, monohydrochloride
CAS Number
522-48-5
Synonyms
  • Tetryzoline
Molecular Formula
C13H16N2 • HCl
Formula Weight
236.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C1(C=CC=C2)=C2C(C3=NCCN3)CCC1.Cl
InChi Code
InChI=1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H
InChi Key
BJORNXNYWNIWEY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $41

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    5 g

    $178

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    10 g

    $312

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    50 g

    $1,260

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    Product Description

    Tetrahydrozoline is an α1-adrenergic receptor (α1-AR) agonist.1 Topical application to the eyes or nasal mucosa activates α1-ARs and induces vasoconstriction in rats, while oral administration activates central α2-ARs resulting in respiratory depression and hypotension in rats and rabbits.1,2,3 Formulations containing tetrahydrozoline have been used to treat eye irritation and nasal congestion.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lev, R., and Clark, R.F. Visine overdose: Case report of an adult with hemodynamic compromise. J. Emerg. Med. 13(5), 649-652 (1995).

    2. Kobinger, W., and Pichler, L. Centrally induced reduction in sympathetic tone - a postsynaptic α-adrenoceptor-stimulating action of imidazolines. Eur. J. Pharmacol. 40(2), 311-320 (1976).

    3. Ruffolo, R.R., Jr., and Waddell, J.E. Receptor interactions of imidazolines: α-Adrenoceptors of rat and rabbit aortae differentiated by relative potencies, affinities and efficacies of imidazoline agonists. Br. J. Pharmacol. 77(1), 169-176 (1982).