A potent and selective PDE5 inhibitor
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Active Metabolite(s)
27843Avanafil metabolite M4
Labeled Version(s)
31687Avanafil-13C-d3
Metabolite(s)
27844Avanafil metabolite M16
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Avanafil

Item No. 23024

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
CAS Number
330784-47-9
Synonyms
  • TA-1790
Molecular Formula
C23H26ClN7O3
Formula Weight
484.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml
λmax
237, 266, 310 nm
SMILES
COC1=CC=C(CNC2=NC(N3CCC[C@H]3CO)=NC=C2C(NCC4=NC=CC=N4)=O)C=C1Cl
InChi Code
InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
InChi Key
WEAJZXNPAWBCOA-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $36

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    250 mg

    $77

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    500 mg

    $128

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    1 g

    $219

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    Product Description

    Avanafil is an orally bioavailable, potent, and competitive inhibitor of phosphodiesterase (PDE) 5 (IC50 = 2.2 nM).1 It is selective, with IC50 values of 630, >5,000, and >5,000 nM for PDE6, PDE1-4, and PDE7-11, respectively, in an enzyme assay. Avanafil potentiates penile tumescence in dogs in a dose-dependent manner. Formulations containing avanafil have been used to treat erectile dysfunction.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kotera, J., Mochida, H., Inoue, H., et al. Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction. J. Urol. 188(2), 668-674 (2012).

    2. Kedia, G.T., Ückert, S., Assadi-Pour, F., et al. Avanafil for the treatment of erectile dysfunction: Initial data and clinical key properties. Ther. Adv. Urol. 5(1), 35-41 (2013).