A potent and selective PDE5 inhibitor
Related Products
Active Metabolite(s)
27843Avanafil metabolite M4
Labeled Version(s)
31687Avanafil-13C-d3
Metabolite(s)
27844Avanafil metabolite M16
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Avanafil

Item No. 23024

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
CAS Number
330784-47-9
Synonyms
  • TA-1790
Molecular Formula
C23H26ClN7O3
Formula Weight
484.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml
λmax
237, 266, 310 nm
SMILES
COC1=CC=C(CNC2=NC(N3CCC[C@H]3CO)=NC=C2C(NCC4=NC=CC=N4)=O)C=C1Cl
InChi Code
InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
InChi Key
WEAJZXNPAWBCOA-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $36

    Add

    250 mg

    $77

    Add

    500 mg

    $128

    Add

    1 g

    $219

    Add
    Product Description

    Avanafil is an orally bioavailable, potent, and competitive inhibitor of phosphodiesterase (PDE) 5 (IC50 = 2.2 nM).1 It is selective, with IC50 values of 630, >5,000, and >5,000 nM for PDE6, PDE1-4, and PDE7-11, respectively, in an enzyme assay. Avanafil potentiates penile tumescence in dogs in a dose-dependent manner. Formulations containing avanafil have been used to treat erectile dysfunction.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kotera, J., Mochida, H., Inoue, H., et al. Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction. J. Urol. 188(2), 668-674 (2012).

    2. Kedia, G.T., Ückert, S., Assadi-Pour, F., et al. Avanafil for the treatment of erectile dysfunction: Initial data and clinical key properties. Ther. Adv. Urol. 5(1), 35-41 (2013).