An adenosine analog
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2'-C-Methyladenosine

Item No. 23062

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2'-C-methyl-adenosine
CAS Number
15397-12-3
Synonyms
  • 2-CMA
Molecular Formula
C11H15N5O4
Formula Weight
281.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mLDMSO: 20 mg/mLPBS (pH 7.2): 10 mg/mL
λmax
259 nm
SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@@](O)(C)[C@H](O)[C@@H](CO)O3
InChi Code
InChI=1S/C11H15N5O4/c1-11(19)7(18)5(2-17)20-10(11)16-4-15-6-8(12)13-3-14-9(6)16/h3-5,7,10,17-19H,2H2,1H3,(H2,12,13,14)/t5-,7-,10-,11-/m1/s1
InChi Key
PASOFFRBGIVJET-YRKGHMEHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    2’-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 µM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 µM.1 It is converted intracellularly to adenosine triphosphate, which inhibits the RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). It also inhibits growth of L. guyanensis in vitro (EC50 = 3 µM) and eradicates it when used at a concentration of 10 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carroll, S.S., Tomassini, J.E., Bosserman, M., et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. The Journal of Biological Chemisty 278(14), 11979-11984 (2003).

    2. Robinson, J.I., and Beverley, S.M. Concentration of 2'C-methyladenosine triphosphate by Leishmania guyanensis enables specific inhibition of Leishmania RNA virus 1 by its RNA polymerase. The Journal of Biological Chemisty (2018).