A phosphorylated form of L-tyrosine
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O-Phospho-L-Tyrosine

Item No. 23064

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-phosphono-L-Tyrosine
CAS Number
21820-51-9
Synonyms
  • Phosphotyrosine
  • P-Tyr
Molecular Formula
C9H12NO6P
Formula Weight
261.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
220 nm
SMILES
OP(OC1=CC=C(C[C@H](N)C(O)=O)C=C1)(O)=O
InChi Code
InChI=1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1
InChi Key
DCWXELXMIBXGTH-QMMMGPOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    100 mg

    $41

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    250 mg

    $80

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    500 mg

    $128

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    Product Description

    O-Phospho-L-tyrosine is a phosphorylated form of L-tyrosine. Tyrosine phosphorylation was originally discovered in proteins containing tyrosines found to be modified by tumor viruses.1 O-phospho-L-tyrosine is used in studies of tyrosine phosphorylation and has been used in affinity chromatography for the purification of IgG.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hunter, T. Phosphotyrosine - a new protein modification. Trends Biochem. Sci. 7(7), 246-249 (1982).

    2. Gmeiner, B., and Seelos, C. Phosphorylation of tyrosine prevents dityrosine formation in vitro. FEBS. Lett. 255(2), 395-397 (1989).

    3. Afonso, A., Pereira, P., Queiroz, J.A., et al. Purification of pre-miR-29 by a new O-phospho-L-tyrosine affinity chromatographic strategy optimized using design of experiments. J. Chromatogr. A. 1343, 119-127 (2014).

    4. Pavan, G.L., Bresolin, I.T.L., Grespan, A., et al. Phosphorylated-tyrosine based pseudobioaffinity adsorbent for the purification of immunoglobulin G. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1052, 10-18 (2017).