A broad spectrum antifungal agent
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AN-2690

Item No. 23101

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
CAS Number
174671-46-6
Synonyms
  • Tavaborole
Molecular Formula
C7H6BFO2
Formula Weight
151.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 3 mg/mlEthanol: 33 mg/ml
λmax
215 nm
SMILES
FC1=CC=C(B(O)OC2)C2=C1
InChi Code
InChI=1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2
InChi Key
LFQDNHWZDQTITF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $107

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    5 g

    $396

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    Cayman Chemical
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    Product Description

    AN-2690 is a broad spectrum antifungal agent with MIC values ranging from 0.25-1 μg/mL against T. rubrum, T. mentagrophytes, C. albicans, C. neoformans, and A. fumigatus.1 It inhibits tRNA aminoacylation (IC50 = 2.1 μM) and hydrolysis of Ile-tRNALeu in a concentration-dependent manner in vitro.2 Formulations containing AN-2690 have been used in the treatment of onychomycosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baker, S.J., Zhang, Y.-K., Akama, T., et al. Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis. J. Med. Chem. 49(15), 4447-4450 (2006).

    2. Rock, F.L., Mao, W., Yaremchuk, A., et al. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science 316(5832), 1759-1761 (2007).