Luliconazole

Luliconazole is a broad spectrum imidazole that is active against various fungi, including Tinea, Candida, Trichophyton, Aspergillus, and Epidermophyton.^1,2 It has MIC values of 2.5-20, 0.63-2.5, 31-250, and ≤0.31-0.63 ng/ml for T. mentagrophytes, T. rubrum, C. albicans, and A. fumigatus, respectively, in broth dilution assays. In vitro, luliconazole has a geometric mean MIC value of 2.35 ng/ml against A. terreus, a fungal species responsible for life-threatening invasive aspergillosis in immunocompromised and high-risk patients.³ It prevents mortality in rats with systemic A. fumigatus infections and in mice with systemic C. albicans infections.² It is effective in eliminating tinea pedis in a guinea pig model when used topically at a concentration of 1% once per day for seven days.¹ Topical formulations containing luliconazole have been used in the treatment of fungal infections.

WARNING This product is not for human or veterinary use.

1. Niwano, Y., Kuzuhara, N., Kodama, J., et al. In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob. Agents and Chemother. 42(4), 967-970 (1998).

2. Niwano, Y., Kuzuhara, N., Goto, Y., et al. Efficacy of NND-502, a novel imidazole antimycotic agent, in experimental models of Candida albicans and Aspergillus fumigatus infections. Int. J. Antimicrob. Agents 12(3), 221-228 (1999).

3. Zargaran, M., Taghipour, S., Kiasat, N., et al. Luliconazole, an alternative antifungal agent against Aspergillus terreus. J. Mycol. Med. 27(3), 351-356 (2017).