A spin label
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4-carboxy TEMPO

Item No. 23139

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-carboxy-2,2,6,6-tetramethyl-1-piperidinyloxy
CAS Number
37149-18-1
Synonyms
  • 4-Carboxyl-2,2,6,6-tetramethylpiperidin-1-oxyl
Molecular Formula
C10H18NO3
Formula Weight
200.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
242 nm
SMILES
CC1(C)N([O])C(C)(C)CC(C(O)=O)C1
InChi Code
InChI=1S/C10H18NO3/c1-9(2)5-7(8(12)13)6-10(3,4)11(9)14/h7H,5-6H2,1-4H3,(H,12,13)
InChi Key
CYQGCJQJIOARKD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $36

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    100 mg

    $66

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    250 mg

    $95

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    500 mg

    $153

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    Product Description

    4-carboxy TEMPO is a nitroxide and spin label.1 Nitroxides such as 4-carboxy TEMPO react with reactive oxygen species (ROS) and can be used with electron spin resonance (ESR) spectroscopy to monitor ROS production in vivo.1,2 It has also been used to study flavin-photosensitized damage in inner mitochondrial membranes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Komarov, A.M., Jospeh, J., and Lai, C.-S. In vivo pharmacokinetics of nitroxides in mice. Biochem. Biophys. Res. Commun. 201(2), 1035-1042 (1994).

    2. Takechi, K., Tamura, H., Yamaoka, K., et al. Pharmacokinetic analysis of free radicals by in vivo BCM (Blood Circulation Monitoring)-ESR method. Free Radic. Res. 26(6), 483-496 (1997).

    3. Mehlhorn, R.J., and Packer, L. Nitroxide destruction and flavin-photosensitized damage in inner mitochondrial membranes. Can. J. Chem. 60(12), 1452-1462 (1982).