A pyrone with diverse biological activities
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Actinopyrone A

Item No. 23140

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one
CAS Number
88378-59-0
Synonyms
  • (+)-Actinopyrone A
  • SS 1538A
Molecular Formula
C25H36O4
Formula Weight
400.6
Purity
≥95%
Formulation (Request formulation change)
An oil
SMILES
COC1=C(C)C(C(C)=C(C/C=C(C)/C/C=C/C(C)=C/[C@@H](C)[C@@H](O)/C(C)=C/C)O1)=O
InChi Code
InChI=1S/C25H36O4/c1-9-18(4)23(26)19(5)15-17(3)12-10-11-16(2)13-14-22-20(6)24(27)21(7)25(28-8)29-22/h9-10,12-13,15,19,23,26H,11,14H2,1-8H3/b12-10+,16-13+,17-15+,18-9+/t19-,23+/m1/s1
InChi Key
PFVSUJLJFXJPMF-DNSWMBNWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

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    Product Description

    Actinopyrone A is a pyrone isolated from S. pactum with diverse biological activities.1 It has selective and potent antimicrobial activity against H. pylori (MIC = 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa, and B. fragilis.1,2 Actinopyrone A also mildly inhibits growth of Gram-positive bacteria and dermatophytes with MIC values ranging from <6.25 to 25 μg/mL.1 Intravenous administration of actinopyrone A (30 μg/kg) increases coronary blood flow in dogs by 196.2%.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yano, K., Yokoi, K., Sato, J., et al. Actinopyrones A, B and C, new physiologically active substances. I. Producing organism, fermentation, isolation and biological properties. J. Antibiot. (Tokyo) 39(1), 32-37 (1986).

    2. Taniguchi, M., Watanabe, M., Nagai, K., et al. γ-pyrone compounds with selective and potent anti-Helicobacter pylori activity. J. Antibiot. (Tokyo) 53(8), 844-847 (2000).