A lipopeptide antibiotic
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Aspartocin D

Item No. 23143

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3Z)-10-methyl-1-oxo-3-undecen-1-yl]-L-α-aspartyl-(2S,3R)-2,3-diaminobutanoyl-(2R)-2-piperidinecarbonyl-(3S)-3-methyl-L-α-aspartyl-L-α-aspartylglycyl-L-α-aspartylglycyl-(2R,3R)-2,3-diaminobutanoyl-L-valyl-L-proline (11→2)-lactam
CAS Number
1211953-97-7
Molecular Formula
C57H89N13O20
Formula Weight
1276.4
Purity
≥85%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O=C([C@H]([C@H](NC([C@@](CCC1)([H])N1C([C@@H](NC([C@@](NC2=O)([H])[C@H](N)C)=O)C(C)C)=O)=O)C)NC([C@H](CC(O)=O)NC(C/C=C\CCCCCC(C)C)=O)=O)N(CCCC3)[C@@]3([H])C(N[C@@](C(N[C@H](C(NCC(N[C@H](C(NC2)=O)CC(O)=O)=O)=O)CC(O)=O)=O)([H])[C@H](C)C(O)=O)=O
InChi Code
InChI=1S/C57H89N13O20/c1-28(2)17-12-10-8-9-11-13-20-38(71)62-35(25-43(78)79)50(82)68-47-32(7)61-51(83)37-19-16-22-70(37)55(87)44(29(3)4)66-54(86)46(31(6)58)65-40(73)27-60-48(80)33(23-41(74)75)63-39(72)26-59-49(81)34(24-42(76)77)64-53(85)45(30(5)57(89)90)67-52(84)36-18-14-15-21-69(36)56(47)88/h11,13,28-37,44-47H,8-10,12,14-27,58H2,1-7H3,(H,59,81)(H,60,80)(H,61,83)(H,62,71)(H,63,72)(H,64,85)(H,65,73)(H,66,86)(H,67,84)(H,68,82)(H,74,75)(H,76,77)(H,78,79)(H,89,90)/b13-11-/t30-,31+,32+,33-,34-,35-,36+,37-,44-,45-,46+,47-/m0/s1
InChi Key
YHIXQCPAIOGTGT-GIOMGZJDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Aspartocin D is a lipopeptide antibiotic originally isolated from S. canus FIM0916.1 It has activity against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.125 and 0.5 μg/ml, respectively). The antibiotic activity is calcium-dependent, with MICs ranging from 0.06-4 and 0.25-8 μg/ml for B. subtilis and S. aureus, respectively, in the presence of higher (2.5 mM) to lower (0.125 mM) calcium concentrations.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, H.J., Huang, X.Z., Zhang, Z.L., et al. Two novel amphomycin analogues from Streptomyces canus strain FIM-0916. Nat. Prod. Res. 28(12), 861-867 (2014).