A monoterpene with diverse biological activities
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p-Cymene

Item No. 23159

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-4-(1-methylethyl)-benzene
CAS Number
99-87-6
Synonyms
  • 4-Cymene
  • para-Cymene
  • NSC 4162
Molecular Formula
C10H14
Formula Weight
134.2
Purity
≥98%
Formulation (Request formulation change)
A neat oil
SMILES
CC(C)C1=CC=C(C)C=C1
InChi Code
InChI=1S/C10H14/c1-8(2)10-6-4-9(3)5-7-10/h4-8H,1-3H3
InChi Key
HFPZCAJZSCWRBC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $103

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    Product Description

    p-Cymene is a monoterpene that is found in a variety of plants, including C. sativa, and has diverse biological activities, including antimicrobial, anticancer, antioxidant, anti-inflammatory, antinociceptive, and anxiolytic properties.1,2 p-Cymene inhibits the growth of S. typhimurium, E. coli, L. monocytogenes, S. epidermidis, and S. aureus with MIC values ranging from 0.266 to 0.608% v/v.3 It decreases the invasive activity of HT-1080 human fibrosarcoma cells in vitro by 87% when used at a concentration of 600 µM.4 In mouse hippocampus, p-Cymene (50 mg/kg, i.p.) reduces lipid peroxidation and nitrite content by 65.5 and 71.2%, respectively, and increases superoxide dismutase (SOD) and catalase activities by 22.7 and 119.3%, respectively, compared to vehicle control animals.5 Formulations containing p-cymene have been used as flavoring agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Marchese, A., Arciola, C.R., Barbieri, R., et al. Update on monoterpenes as antimicrobial agents: A particular focus on p-cymene. Materials (Basel) 10(8), pii: E947 (2017).

    2. Nigam, M.C., Handa, K.L., Nigam, I.C., et al. Essential oils and their constitutents: XXIX. The essential oil of marihuana: Composition of genuine indian Cannabis sativa L. Can. J. Chem. 43(12), 3372-3376 (1965).

    3. Mitropoulou, G., Fitsiou, E., Stravropoulou, E., et al. Composition, antimicrobial, antioxidant, and antiproliferative activity of Origanum dictamnus (dittany) essential oil. Microb. Ecol. Health Dis. 26:26543, (2015).

    4. Li, J., Liu, C., and Sato, T. Novel antitumor invasive actions of p-cymene by decreasing MMP-9/TIMP-1 expression ratio in human fibrosarcoma HT-1080 cells. Biol. Pharm. Bull. 39(8), 1247-1253 (2016).

    5. de Oliveira, T.M., de Carvalho, R.B., da Costa, I.H., et al. Evaluation of p-cymene, a natural antioxidant. Pharm. Biol. 53(3), 423-428 (2015).