(+)-Valencene

(+)-Valencene is a sesquiterpene that has been found in C. sativa and is an aromatic component of orange essence oil.^1,2 (+)-Valencene (50 µM) induces heme oxgenase-1 (HO-1) expression in macrophages and inhibits the expression of inducible nitric oxide synthase (iNOS), the production of nitric oxide (NO), and the release of high-mobility group box-1 (HMGB1) in RAW 264.7 cells stimulated with LPS.³ It also increases the survival rate in a mouse model of sepsis induced by cecal ligation and puncture. (+)-Valencene has been used in the synthesis of nootkatone (Item No. 24910).⁴

WARNING This product is not for human or veterinary use.

1. Naz, S., Hanif, M.A., Bhatti, H.N., et al. Impact of supercritical fluid extraction and traditional distillation on the isolation of aromatic compounds from Cannabis indica and Cannabis sativa. J. Essent. Oil Bearing Plants 20(1), 175-184 (2017).

2. Högnadóttir , A., and Rouseff, R.L. Identification of aroma active compounds in orange essence oil using gas chromatography-olfactometry and gas chromatography-mass spectrometry. J. Chromatogr. A. 998(1-2), 201-211 (2003).

3. Tsoyi, K., Jang, H.J., Lee, Y.S., et al. (+)-Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction. J. Ethnopharmacol. 137(3), 1311-1317 (2011).

4. Kolwek, J., Behrens, C., Linke, D., et al. Cell-free one-pot conversion of (+)-valencene to (+)-nootkatone by a unique dye-decolorizing peroxidase combined with a laccase from Funalia trogii. J. Ind. Microbiol. Biotechnol. 45(2), 89-101 (2018).