A sesquiterpene with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Nerolidol

Item No. 23182

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7,11-trimethyl-1,6,10-dodecatrien-3-ol
CAS Number
7212-44-4
Synonyms
  • (±)-Nerolidol
Molecular Formula
C15H26O
Formula Weight
222.4
Purity
≥95%
Formulation (Request formulation change)
An oil
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Slightly Soluble
SMILES
C=CC(O)(C)CC/C=C(C)/CC/C=C(C)/C
InChi Code
InChI=1S/C15H26O/c1-6-15(5,16)12-8-11-14(4)10-7-9-13(2)3/h6,9,11,16H,1,7-8,10,12H2,2-5H3/b14-11+
InChi Key
FQTLCLSUCSAZDY-SDNWHVSQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 g

    $36

    Add

    25 g

    $48

    Add

    50 g

    $86

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Nerolidol is a sesquiterpene found in a variety of plants, including C. sativa, that has diverse biological activities, including antioxidant, anthelmintic, antinociceptive, and anti-inflammatory properties.1,2,3,4,5 It decreases superoxide dismutase (SOD) and catalase activity, reduces glutathione (GSH) levels, and increases malondialdehyde (MDA) levels in the brain when administered at a dose of 50 mg/kg in a rat model of Parkinson’s disease induced by rotenone (Item No. 13995).3 It also inhibits rotenone-induced increases in IL-1β, IL-6, and TNF-α in rat brain. Nerolidol (100, 200, and 400 mg/kg) reduces worm burden and egg production in a mouse model of schistosomiasis.4 It also decreases acetic acid-induced writhing and formalin-induced licking time in mice, indicating antinociceptive activity, and reduced carrageenan-induced paw edema when administered at doses of 300 and 400 mg/kg.5 Formulations containing nerolidol have been used as fragrance ingredients.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ruzicka, L. Higher terpene compounds. VIII. Constitution of nerolidol (peruviol). Helv. Chim. Acta. 6, 483-492 (1923).

    2. Marchini, M., Charvoz, C., Dujourdy, L., et al. Multidimensional analysis of cannabis volatile constituents: Identification of 5,5-dimethyl-1-vinylbicyclo[2.1.1]hexane as a volatile marker of hashish, the resin of Cannabis sativa L. J. Chromatogr. A. 1370, 200-215 (2014).

    3. Javed, H., Azimullah, S., Abul Khair, S.B., et al. Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone. BMC Neurosci. 17(1), 58 (2016).

    4. Silva, M.P., de Oliveira, R.N., Mengarda, A.C., et al. Antiparasitic activity of nerolidol in a mouse model of schistosomiasis. Int. J. Antimicrob. Agents 50(3), 467-472 (2017).

    5. Fonseca, D.V., Salgado, P.R., de Carvalho, F.L., et al. Nerolidol exhibits antinociceptive and anti-inflammatory activity: Involvement of the GABAergic system and proinflammatory cytokines. Fundam. Clin. Pharmacol. 30(1), 14-22 (2016).