A component of anthrax toxin
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Anthrax Lethal Factor (recombinant from Bacillus anthracis) Modified Sequence, (LF-HMA)

Item No. 23216

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Purity
≥90% (estimated by SDS-PAGE)
Formulation (Request formulation change)
Each vial, when reconstituted with 0.5 ml of water, contains 1 mg of lethal factor from Bacillus anthracis in 5 mM HEPES, 50 mM sodium chloride, pH 7.5
Origin
Bacterium/Bacillus anthracis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $1,003

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    Product Description

    Anthrax lethal factor is one component of a tripartite protein toxin secreted into host systems during anthrax infection caused by B. anthracis.1 The toxin is a mixture of three protein components: Lethal factor, edema factor, and protective antigen. Lethal factor is a zinc-dependent metalloprotease that disrupts MAPK signaling by cleaving MAPK kinases near the N-terminal end. It requires protective antigen, but not edema factor, for its lethality.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pannifer, A.D., Wong, T.Y., Schwarzenbacher, R., et al. Crystal structure of the anthrax lethal factor. Nature 414(6860), 229-233 (2001).