An inactive diphtheria toxin
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Diphtheria Toxin CRM197 mutant from Corynebacterium diphtheriae

Item No. 23218

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Purity
≥90% (estimated by SDS-PAGE)
Formulation (Request formulation change)
Each vial, when reconstituted to 0.25 ml with water, contains 250 µg of diphtheria toxin CRM197 mutant in 0.01 M sodium phosphate with 5% lactose at pH 7.4
Solubility(Learn about Variance in Solubility)
Water: soluble
Shipping & Storage Information
Storage
2°C to 8°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    250 µg

    $597

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Diphtheria toxin CRM197 mutant from C. diphtheriae is an inactive and non-toxic version of diphtheria toxin. It contains a single base change in the structural gene resulting in the substitution of glutamic acid for glycine which blocks ADP-ribosylation.1 Diphtheria toxin CRM197 mutant has no enzymatic activity but is immunologically indistinguishable from diphtheria toxin. Formulations containing diphtheria toxin CRM197 mutant have been used as carriers of conjugated polysaccharides in the development of vaccines against encapsulated bacterial pathogens.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pappenheimer, A.M., Jr., Uchida, T., and Harper, A.A. An immunological study of the diphtheria toxin molecule. Immunochemistry 9(9), 891-906 (1972).

    2. Benaissa-Trouw, B., Lefeber, D.J., Kamerling, J.P., et al. Synthetic polysaccharide type 3-related di-, tri-, and tetrasaccharide-CRM197 conjugates induce protection against Streptococcus pneumoniae type 3 in mice. Infect. Immun. 69(7), 4698-4701 (2001).