A toxin used in GPCR and EAE research
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Pertussis Toxin from Bordetella pertussis (in glycerol)

Item No. 23220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Purity
≥95% (estimated by SDS-PAGE)
Formulation (Request formulation change)
50 μg of pertussis toxin in 50% glycerol, 0.05 M Tris, 0.01 M glycine, 0.5 M sodium chloride, pH 7.5, at a concentration of 0.15 mg/ml
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $523

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    Product Description

    Pertussis toxin was first isolated from B. pertussis and is used to study G protein-coupled receptor signaling in cells and experimental autoimmune encephalomyelitis (EAE) in animals. Pertussis toxin catalyzes the transfer of the ADP-ribose moiety of NAD to the α subunits of heterotrimeric Gi/o proteins, resulting in the receptors being uncoupled from Gi/o proteins.1,2 Pertussis toxin is also used as an adjuvant, given with specific antigens, to immunize animals and induce EAE, an animal model of multiple sclerosis.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaslow, H.R., and Burns, D.L. Pertussis toxin and target eukaryotic cells: Binding, entry, and activation. The FASEB Journal 6(9), 2684-2690 (1992).

    2. Ui, M. Islet-activating protein, pertussis toxin: A probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase. Trends Pharmacol. Sci. 5, 277-279 (1984).

    3. Davenport, K.R., Smith, C.A., Hofstetter, H., et al. Site-directed immobilization of a genetically engineered anti-methotrexate antibody via an enzymatically introduced biotin label significantly increases the binding capacity of immunoaffinity columns. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1021, 114-121 (2016).

    4. Ronchi, F., Basso, C., Preite, S., et al. Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells. Nat. Commun. 7:11541, (2016).