A nicotinamide derivative
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Product Type

Small Molecule Modulators
Small Molecule Inhibitors

Research Area

Cell Biology

1-Methyl-1,4-dihydronicotinamide

Item No. 23226

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-1-methyl-3-pyridinecarboxamide
CAS Number
17750-23-1
Molecular Formula
C7H10N2O
Formula Weight
138.2
Purity
≥90%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlEthanol: 2.5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
356 nm
SMILES
O=C(N)C1=CN(C)C=CC1
InChi Code
InChI=1S/C7H10N2O/c1-9-4-2-3-6(5-9)7(8)10/h2,4-5H,3H2,1H3,(H2,8,10)
InChi Key
HOERLBZJYLYWEY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $36

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    10 mg

    $68

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    25 mg

    $145

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    50 mg

    $219

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    Product Description

    1-Methyl-1,4-dihydronicotinamide is a derivative of nicotinamide (Item No. 11127).1 It inhibits β-elimination activity of human serine racemase (hSR; IC50 = 177 μM) through binding to an allosteric and hydrophobic site on the enzyme.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bruno, S., Marchesani, F., Dellafiora, L., et al. Human serine racemase is allosterically modulated by NADH and reduced nicotinamide derivatives. Biochem J. 473(20), 3505-3516 (2016).