A class Ia antiarrhythmic agent and sodium channel blocker
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Disopyramide

Item No. 23227

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-pyridineacetamide
CAS Number
3737-09-5
Synonyms
  • (±)-Disopyramide
  • Ritmilen
  • SC-7031
Molecular Formula
C21H29N3O
Formula Weight
339.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleEthanol: >1 mg/mlMethanol: slightly soluble
λmax
262 nm
SMILES
O=C(N)C(C1=CC=CC=C1)(CCN(C(C)C)C(C)C)C2=CC=CC=N2
InChi Code
InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
InChi Key
UVTNFZQICZKOEM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $44

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    1 g

    $71

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    5 g

    $260

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    Product Description

    Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels.1 It is a class Ia antiarrhythmic agent that delays conduction through the AV node and ventricles of the dog heart both in vivo (3 and 5 mg/kg) and in vitro (1-2 mg/L).2 Formulations containing disopyramide have been used in the treatment of cardiac arrhythmias and hypertrophic cardiomyopathy.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grant, A.O., Wendt, D.J., Zilberter, Y., et al. Kinetics of interaction of disopyramide with the cardiac sodium channel: Fast dissociation from open channels at normal rest potentials. J. Membr. Biol. 136(2), 199-214 (1993).

    2. Yeh, B.K., Sung, P.-K., and Scherlag, B.J. Effects of disopyramide on electrophysiological and mechanical properties of the heart. J. Pharm. Sci. 62(12), 1924-1929 (1973).

    3. Verlinden, N.J., and Coons, J.C. Disopyramide for hypertrophic cardiomyopathy: A pragmatic reappraisal of an old drug. Pharmacotherapy 35(12), 1164-1172 (2015).