A broad-spectrum antibiotic
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Tropodithietic Acid

Item No. 23244

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
CAS Number
750590-18-2
Synonyms
  • TDA
Molecular Formula
C8H4O3S2
Formula Weight
212.2
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C1C=CC=C2C(SS2)=C1C(O)=O
InChi Code
InChI=1S/C8H4O3S2/c9-4-2-1-3-5-7(13-12-5)6(4)8(10)11/h1-3H,(H,10,11)
InChi Key
BLFCMITWMARUSM-UHFFFAOYSA-N
Origin
Bacterium/Roseobacter gallaeciensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $189

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    Product Description

    Tropodithietic acid (TDA) is a broad-spectrum antibiotic produced by the marine bacterium R. gallaeciensis.1 It is active against a variety of Gram-negative α-proteobacteria, γ-proteobacteria, and flavobacteria as well as Gram-positive actinobacteria strains in a disc assay. TDA also inhibits the growth of S. aureus and V. anguillarum with MIC values of 39 and 19 μM, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brinkhoff, T., Bach, G., Heidorn, T., et al. Antibiotic production by a Roseobacter clade-affiliated species from the German Wadden Sea and its antagonistic effects on indigenous isolates. Appl. Environ. Microbiol. 70(4), 2560-2565 (2004).

    2. Rabe, P., Klapschinski, T.A., Brock, N.L., et al. Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid. Beilstein J. Org. Chem. 10, 1796-1801 (2014).