A sulfated polysaccharide
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Dextran sulfate (sodium salt) (MW 40,000)

Item No. 23250

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
dextran, hydrogen sulfate, sodium salt
CAS Number
9011-18-1
Synonyms
  • DSS​
Formula Weight
40000.0
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
270 nm
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $65

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    25 g

    $138

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    50 g

    $228

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    100 g

    $325

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    Product Description

    Dextran sulfate (MW 40,000) is a sulfated polysaccharide of variable molecular weight ranging from 5 to 1,400 kDa.1 Oral administration of dextran sulfate (MW 40,000) induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate (MW 40,000) has also been used in molecular biology applications including precipitation of lipoproteins, acceleration of DNA probe hybridization to nucleic acids, and ribosomal isolations.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chassaing, B., Aitken, J.D., Malleshappa, M., et al. Dextran sulfate sodium (DSS)-induced colitis in mice. Curr. Protoc. Immunol. 104, Unit 15.25 (2014).

    2. Burstein, M., Scholnick, H.R., and Morfin, R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res. 11(6), 583-595 (1970).

    3. Wahl, G.M., Stern, M., and Stark, G.R. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc. Natl. Acad. Sci. USA 76(8), 3683-3687 (1979).

    4. Ascione, R., and Arlinghaus, R.B. Characterization and cell-free activity of polyribosomes isolated from baby hamster kidney cells. Biochim. Biophys. Acta 204(2), 478-488 (1970).

    Product Citations

    Liu, D., and Kong, D.-R. Investigating the impact of hsa_circ_0005255 on proliferation and autophagy in Crohn’s disease intestinal epithelial cells through miR-23a-3p-mediated NCOA3 expression. Kaohsiung J. Med. Sci. e70035 (2025).

    Bao, X., Li, Q., Chen, D., et al. A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer. Cell Rep. Med. 5(2), 101399 (2024).

    Chougule, P.R., Sangaraju, R., Patil, P.B., et al. Effect of ethyl gallate and propyl gallate on dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6 J mice: Preventive and protective. Inflammopharmacology 31(4), 2103-2120 (2023).

    La Rocca, G., King, B., Shui, B., et al. Inducible and reversible inhibition of miRNA-mediated gene repression in vivo. Elife 10:e70948, (2021).