A potent and selective SPHK1 inhibitor
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SLP7111228 (hydrochloride)

Item No. 23290

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-[[3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-1-pyrrolidinecarboximidamide, monohydrochloride
CAS Number
1449768-48-2
Molecular Formula
C22H33N5O • HCl
Formula Weight
420.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12.5 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
249 nm
SMILES
CCCCCCCCC1=CC=C(C2=NOC(C[C@H]3N(C(N)=N)CCC3)=N2)C=C1.Cl
InChi Code
InChI=1S/C22H33N5O.ClH/c1-2-3-4-5-6-7-9-17-11-13-18(14-12-17)21-25-20(28-26-21)16-19-10-8-15-27(19)22(23)24;/h11-14,19H,2-10,15-16H2,1H3,(H3,23,24);1H/t19-;/m0./s1
InChi Key
REAGUXWEQBFUPB-FYZYNONXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $202

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    10 mg

    $354

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    25 mg

    $762

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    Product Description

    SLP7111228 is a potent and selective inhibitor of sphingosine kinase (SPHK) 1 with Ki values of 0.048 and >10 μM for SPHK1 and 2, respectively.1 It induces a concentration-dependent decrease in sphingosine-1-phosphate (S1P; Item No. 62570) in U937 cells but has no effect on sphingosine levels. In vivo, SLP7111228 decreases blood levels of S1P in a dose-dependent manner in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patwardhan, N.N., Morris, E.A., Kharel, Y., et al. Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors. J. Med. Chem. 58(4), 1879-1899 (2015).