An intermediate in the citric acid cycle
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Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Cofactors & Vitamins

Succinyl-Coenzyme A (sodium salt)

Item No. 23297

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-(hydrogen butanedioate), coenzyme A, sodium salt
CAS Number
108347-97-3
Synonyms
  • Succinyl-CoA
Molecular Formula
C25H40N7O19P3S • XNa
Formula Weight
867.6
Purity
≥70%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
258 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC(O)=O)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na]
InChi Code
InChI=1S/C25H40N7O19P3S.Na/c1-25(2,20(38)23(39)28-6-5-14(33)27-7-8-55-16(36)4-3-15(34)35)10-48-54(45,46)51-53(43,44)47-9-13-19(50-52(40,41)42)18(37)24(49-13)32-12-31-17-21(26)29-11-30-22(17)32;/h11-13,18-20,24,37-38H,3-10H2,1-2H3,(H,27,33)(H,28,39)(H,34,35)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42);/t13-,18-,19-,20+,24-;/m1./s1
InChi Key
MZSOFLIDFHDGAA-YXKORUMSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $72

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    5 mg

    $269

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    10 mg

    $466

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    Product Description

    Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle.1 It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis.2 Succinyl-CoA deficiency, caused by vitamin B12 (Item No. 18425) deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meister, A. ACYL phosphates as enzyme-bound intermediates in the biosynthesis of glutamine, glutathione, succinyl, coenzyme A, and cabamyl phosphate. Trans. N. Y. Acad. Sci. 30(8), 1157-1180 (1968).

    2. Bonkovsky, H.L., Guo, J.-T., Hou, W., et al. Porphyrin and heme metabolism and the porphyrias. Compr Physiol 3(1), 365-401 (2013).

    3. Bicakci, Z. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis. Medicine (Baltimore) 94(9), e584 (2015).