An equine estrogen
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Equilenin

Item No. 23322

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-estra-1,3,5,7,9-pentaen-17-one
CAS Number
517-09-9
Synonyms
  • (+)-Equilenin
  • d-Equilenin
  • NSC 9901
Molecular Formula
C18H18O2
Formula Weight
266.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: SolubleMethanol: soluble
SMILES
O=C1CC[C@@]([C@]1(C)CC2)([H])C3=C2C4=CC=C(O)C=C4C=C3
InChi Code
InChI=1S/C18H18O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h2-5,10,16,19H,6-9H2,1H3/t16-,18-/m0/s1
InChi Key
PDRGHUMCVRDZLQ-WMZOPIPTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

    $202

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    Product Description

    Equilenin is an equine estrogen found in the urine of pregnant mares.1 Unlike naturally occurring human estrogens, equilenin has no effect on nitric oxide synthase (eNOS) activity or expression and does not increase production of nitric oxide (NO). It is metabolized to 4-hydroxyequilenin, a carcinogenic compound that induces transformation of C3H 10T½ murine fibroblasts.2 Formulations containing equilenin conjugates have been widely used as hormone replacement therapies for post-menopausal women.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Novensa, L., Selent, J., Pastor, M., et al. Equine estrogens impair nitric oxide production and endothelial nitric oxide synthase transcription in human endothelial cells compared with the natural 17β-estradiol. Hypertension 56(3), 405-411 (2010).

    2. Spink, D.C., Zhang, F., Hussain, M.M., et al. Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells. Chem. Res. Toxicol. 14(5), 572-581 (2001).