An inhibitor of TGF-β
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ITD 1

Item No. 23326

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid, ethyl ester
CAS Number
1099644-42-4
Molecular Formula
C27H29NO3
Formula Weight
415.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml
λmax
245, 368 nm
SMILES
O=C1CC(C)(C)CC2=C1C(C3=CC=C(C4=CC=CC=C4)C=C3)C(C(OCC)=O)=C(C)N2
InChi Code
InChI=1S/C27H29NO3/c1-5-31-26(30)23-17(2)28-21-15-27(3,4)16-22(29)25(21)24(23)20-13-11-19(12-14-20)18-9-7-6-8-10-18/h6-14,24,28H,5,15-16H2,1-4H3
InChi Key
ULFUJLFTRWWLPO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $161

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    25 mg

    $354

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    50 mg

    $653

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    Product Description

    ITD 1 is an inhibitor of TGF-β (IC50 = 0.85 µM).1 It is selective for TGF-β in an SBE4/Smad reporter assay, providing 83% inhibition when used at a concentration of 2.5 µM, over activin A, which is inhibited by 51% when used at the same concentration. ITD 1 inhibits TGF-β signaling by induction of TGF-β receptor type II degradation. It stimulates differentiation of mouse embryonic stem cells (mESCs) into cardiomyocytes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schade, D., Lanier, M., Willems, E., et al. Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling. J. Med. Chem. 55(22), 9946-9957 (2012).