A p18 inhibitor that promotes HSC expansion
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

NSC 23005 (sodium salt)

Item No. 23327

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(cyclohexylamino)sulfonyl]-benzoic acid, monosodium salt
CAS Number
1796596-46-7
Molecular Formula
C13H16NO4S • Na
Formula Weight
305.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.2 mg/mlDMSO: 1 mg/mlEthanol: 0.2 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
202, 239 nm
SMILES
O=S(NC1CCCCC1)(C2=CC=C(C([O-])=O)C=C2)=O.[Na+]
InChi Code
InChI=1S/C13H17NO4S.Na/c15-13(16)10-6-8-12(9-7-10)19(17,18)14-11-4-2-1-3-5-11;/h6-9,11,14H,1-5H2,(H,15,16);/q;+1/p-1
InChi Key
MLHFBDVMTRIQMW-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $38

    Add

    5 mg

    $110

    Add

    10 mg

    $183

    Add
    Product Description

    NSC 23005 is a small molecule inhibitor of p18, as determined by an in silico screen.1 It promotes expansion of murine and human hematopoietic stem cells (HSCs) with an ED50 value of 5.21 nM in a single-cell in vitro culture assay using isolated murine bone marrow cells. NSC 23005 increases the number of long-term HSCs following treatment with a CDK2 inhibitor but not a CDK4/6 inhibitor, indicating that it mediates its effects by blocking p18 inhibition of CDK4/6. It increases HSC proliferation without affecting differentiation, inducing cytotoxicity, or affecting leukemia cell proliferation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xie, X.Q., Yang, P., Zhang, Y., et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci. Rep. 5, 18115 (2015).