An HIV-1 Vif inhibitor
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RN-18

Item No. 23331

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-methoxyphenyl)-2-[(4-nitrophenyl)thio]-benzamide
CAS Number
431980-38-0
Molecular Formula
C20H16N2O4S
Formula Weight
380.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/mlEthanol: slightly soluble
λmax
332 nm
SMILES
O=C(NC1=C(OC)C=CC=C1)C2=CC=CC=C2SC3=CC=C([N+]([O-])=O)C=C3
InChi Code
InChI=1S/C20H16N2O4S/c1-26-18-8-4-3-7-17(18)21-20(23)16-6-2-5-9-19(16)27-15-12-10-14(11-13-15)22(24)25/h2-13H,1H3,(H,21,23)
InChi Key
JKNUDHUHXMELIJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    RN-18 is an inhibitor of HIV-1 viral infectivity factor (Vif), an HIV-1 regulatory protein that does not have cellular homologs.1 RN-18 inhibits Vif-mediated degradation of the DNA editing enzyme APOBEC3G with IC50 values of 10-30 µM in a high-throughput fluorescence screen. It inhibits viral replication of HIV-1 with IC50 values of 4.5 and 10 µM for nonpermissive CEM and H9 cells, respectively, and >100 µM for permissive cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nathans, R., Cao, H., Sharova, N., et al. Small-molecule inhibition of HIV-1 Vif. Nat. Biotechnol. 26(10), 1187-1192 (2008).