An adenylyl cyclase type I and VI inhibitor
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CB-7921220

Item No. 23332

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[2-(4-aminophenyl)ethenyl]-2-pyridinecarboxylic acid
CAS Number
115453-99-1
Molecular Formula
C14H12N2O2
Formula Weight
240.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 0.3 mg/ml
λmax
353 nm
SMILES
NC(C=C1)=CC=C1/C=C/C2=NC(C(O)=O)=CC=C2
InChi Code
InChI=1S/C14H12N2O2/c15-11-7-4-10(5-8-11)6-9-12-2-1-3-13(16-12)14(17)18/h1-9H,15H2,(H,17,18)/b9-6+
InChi Key
QASPDWZDKLUOPO-RMKNXTFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $37

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    5 mg

    $158

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    10 mg

    $280

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    25 mg

    $609

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    Product Description

    CB-7921220 is an inhibitor of the adenylyl cyclase (AC) isoforms AC1 and AC6.1 It is selective, reducing AC1 and AC6 activity by 60% while having no effect on AC2 and AC5 in Sf9 membranes stimulated by forskolin (Item No. 11018) when used at a concentration of 100 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brand, C.S., Hocker, H.J., Gorfe, A.A., et al. Isoform selectivity of adenylyl cyclase inhibitors: Characterization of known and novel compounds. J. Pharmacol. Exp. Ther. 347(2), 265-275 (2013).