L-Allylglycine

L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations.¹ L-Allylglycine (1.2 mmol/kg, i.p.) induces convulsions and decreases GABA concentration throughout the cerebellum, pons, medulla, striatum, cortex, and hippocampus in mice.² Chronic administration (3.2 μg/0.5 μl per hour for 13 days) of L-allylglycine in rats increases locomotor activity in an open field test and impairs attention in the 5-choice serial reaction time task (5CSRTT).³ In vitro, L-allylglycine inhibits GAD only when used at high concentrations (1-80 mM). The more potent in vivo activity can be attributed to metabolic conversion of L-allylglycine to 2-keto-4-pentanoic acid, a more potent convulsant and GAD inhibitor.

WARNING This product is not for human or veterinary use.

1. Orlowski, M., Reingold, D.F., and Stanley, M.E. D-and L-stereoisomers of allylglycine: convulsive action and inhibition of brain L-glutamate decarboxylase. J. Neurochem. 28(2), 349-353 (1977).

2. Horton, R.W., Chapman, A.G., and Meldrum, B.S. Regional changes in cerebral GABA concentration and convulsions produced by D and by L-allylglycine. J. Neurochem. 30(6), 1501-1504 (1978).

3. Paine, T.A., Cooke, E.K., and Lowes, D.C. Effects of chronic inhibition of GABA synthesis on attention and impulse control. Pharmacol. Biochem. Behav. 135, 97-104 (2015).