An inhibitor of GABA uptake
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Guvacine (hydrochloride)

Item No. 23361

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, monohydrochloride
CAS Number
6027-91-4
Molecular Formula
C6H9NO2 • HCl
Formula Weight
163.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.25 mg/mlDMSO: 20 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
OC(C1=CCCNC1)=O.Cl
InChi Code
InChI=1S/C6H9NO2.ClH/c8-6(9)5-2-1-3-7-4-5;/h2,7H,1,3-4H2,(H,8,9);1H
InChi Key
FGNUNVVTHHKDAM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $63

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    50 mg

    $112

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    100 mg

    $218

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    250 mg

    $481

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    Product Description

    Guvacine is an amino acid found in A. catechu (Betel nut).1 It competitively inhibits GABA uptake (IC50 = 10 μM; Ki = 14 μM) in rat hippocampal brain slices.1,2 In vivo, guvacine, at doses ranging from 50-100 mg/kg, decreases spontaneous activity in mice.1 Administration of guvacine also decreases tail flick reaction time in a rat model of morphine analgesia.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnston, G.A., Krogsgaard-Larsen, P., and Stephanson, A. Betel nut constituents as inhibitors of γ-aminobutyric acid uptake. Nature 258(5536), 627-628 (1975).

    2. Pavia, M.R., Lobbestael, S.J., Nugiel, D., et al. Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake. J. Med. Chem. 35(22), 4238-4248 (1992).

    3. Mantegazza, P., Tammiso, R., Vicentini, L., et al. Nipecotic acid and guvacine antagonism on morphine analgesia in rats. Pharmacol. Res. Commun. 11(8), 657-662 (1979).