An inhibitor of estrone sulfatase
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Isomer(s)
381214-Hydroxyphenylglyoxylic Acid
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3-Formylsalicylic Acid

Item No. 23368

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-formyl-2-hydroxy-benzoic acid
CAS Number
610-04-8
Synonyms
  • NSC 55753
Molecular Formula
C8H6O4
Formula Weight
166.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
λmax
221, 329 nm
SMILES
O=CC1=CC=CC(C(O)=O)=C1O
InChi Code
InChI=1S/C8H6O4/c9-4-5-2-1-3-6(7(5)10)8(11)12/h1-4,10H,(H,11,12)
InChi Key
YOEUNKPREOJHBW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $34

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    50 mg

    $68

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    100 mg

    $102

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    250 mg

    $187

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    Product Description

    3-Formylsalicylic acid is a non-competitive inhibitor of estrone sulfatase (IC50 = 150 nM; Ki = 120 nM), the enzyme that converts estrone sulfate to estrone.1 3-Formylsalicylic acid has been used in the synthesis of Schiff bases.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jütten, P., Schumann, W., Härtl, A., et al. Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J. Med. Chem. 50(15), 3661-3666 (2007).

    2. Sarkar, S., and Dey, K. Synthesis and spectroscopic characterization of some transition metal complexes of a new hexadentate N2S2O2 Schiff base ligand. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 62(1-3), 383-393 (2005).

    3. Hadi, J.S., and Althahabi, N.K. Synthesis, spectroscopic characterization and biological activity of some new sulfa drug Schiff bases. Res. J. Pharm. Biol. Chem. Sci. 5(3), 856-866 (2014).