A sulfonamide antibiotic
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Sulfamerazine (sodium salt)

Item No. 23380

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-N-(4-methyl-2-pyrimidinyl)-benzenesulfonamide, monosodium salt
CAS Number
127-58-2
Molecular Formula
C11H11N4O2S • Na
Formula Weight
286.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
268 nm
SMILES
NC1=CC=C(S([N-]C2=NC(C)=CC=N2)(=O)=O)C=C1.[Na+]
InChi Code
InChI=1S/C11H11N4O2S.Na/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10;/h2-7H,12H2,1H3;/q-1;+1
InChi Key
BSFJGCCAXDCMOX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Sulfamerazine is a sulfonamide antibiotic.1 It inhibits dihydropteroate synthase (DHPS; IC50 = 11.26 ng/ml for the S. pneumoniae enzyme) and bacterial carbonic anhydrase by ~20% when used at a concentration of 500 μM.2,3 In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice.4 It also prevents death of Toxoplasma-infected mice.1 Formulations containing sulfamerazine have been used in the treatment of coccidiosis and acute fowl cholera in poultry.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Summers, W.A. The effects of oral administration of aureomycin, sulfathiazole, sulfamerazine and 4,4'-diamino diphenyl sulfone on toxoplasmosis in mice. Am. J. Trop. Med. Hyg. 29(6), 889-893 (1949).

    2. Wang, Z., Liang, X., Wen, K., et al. A highly sensitive and class-specific fluorescence polarisation assay for sulphonamides based on dihydropteroate synthase. Biosens. Bioelectron. 70, 1-4 (2015).

    3. al-Rashida, M., Hussain, S., Hamayoun, M., et al. Sulfa drugs as inhibitors of carbonic anhydrase: New targets for the old drugs. Biomed. Res. Int. 162928 (2014).

    4. Matsushita, S., and Suzuki, E. Prevention and treatment of cilia-associated respiratory bacillus in mice by use of antibiotics. Lab. Anim. Sci. 45(5), 503-507 (1995).