An antibiotic
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Gamithromycin

Item No. 23389

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one
CAS Number
145435-72-9
Synonyms
  • ML-1709460
Molecular Formula
C40H76N2O12
Formula Weight
777.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 5 mg/mlEthanol: 16 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
CN(C)[C@@H](C[C@@H](C)O1)[C@@H](O)[C@]1([H])O[C@H]2[C@](C)(O)C[C@@H](C)N(CCC)C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC([C@H](C)[C@@H](O[C@@]3([H])C[C@](OC)(C)[C@@H](O)[C@H](C)O3)[C@@H]2C)=O
InChi Code
InChI=1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25-,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1
InChi Key
VWAMTBXLZPEDQO-UZSBJOJWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $90

    Add

    25 mg

    $207

    Add

    50 mg

    $392

    Add

    100 mg

    $696

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Gamithromycin is an antibiotic that is active against macrolide-resistant R. equi and S. zooepidemicus (MIC90s = 1 and 0.125 μg/ml, respectively).1 It reduces the number of pneumonic lesions in a bovine M. haemolytica challenge model at a dose of 6 mg/kg.2 Formulations containing gamithromycin have been used to treat bovine respiratory diseases.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berghaus, L.J., Giguère, S., Sturgill, T.L., et al. Plasma pharmacokinetics, pulmonary distribution, and in vitro activity of gamithromycin in foals. J. Vet. Pharmacol. Ther. 35(1), 59-66 (2012).

    2. Forbes, A.B., Ramage, C., Sales, J., et al. Determination of the duration of antibacterial efficacy following administration of gamithromycin using a bovine Mannheimia haemolytica challenge model. Antimicrob. Agents Chemother. 55(2), 831-835 (2011).

    3. Capik, S.F., White, B.J., Lubbers, B.V., et al. Comparison of the diagnostic performance of bacterial culture of nasopharyngeal swab and bronchoalveolar lavage fluid samples obtained from calves with bovine respiratory disease. Am. J. Vet. Res. 78(3), 350-358 (2017).