An inhibitor of eIF2α dephosphorylation
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Product Type

Biochemicals

Research Area

Neuroscience
Behavioral Neuroscience
Learning & Memory

Sal-003

Item No. 23414

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-3-phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide
CAS Number
1164470-53-4
Molecular Formula
C18H15Cl4N3OS
Formula Weight
463.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
217, 277 nm
SMILES
ClC1=CC=C(NC(NC(C(Cl)(Cl)Cl)NC(/C=C/C2=CC=CC=C2)=O)=S)C=C1
InChi Code
InChI=1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+
InChi Key
TVNBASWNLOIQML-IZZDOVSWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $171

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    Product Description

    Sal-003 dose-dependently prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α).1 It is a more potent derivative of salubrinal (Item No. 14735) that increases eIF2α phosphorylation in mouse embryonic fibroblasts (MEFs) when used at a concentration of 10 µM.2 It impairs late-phase long-term potentiation (LTP) in hippocampal slices from wild-type, but not ATF4 knockout, mice. When infused into the dorsal hippocampus post-training, Sal-003 impairs contextual fear memory in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Robert, F., Kapp, L.D., Khan, S.N., et al. Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2 • GTP • Met-tRNAiMet ternary complex availability. Mol. Biol. Cell 17(11), 4632-4644 (2006).

    2. Costa-Mattioli, M., Gobert, D., Stern, E., et al. eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell 129(1), 195-206 (2007).