A PEGylated version of biotin-azide
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Product Categories

Product Type

Biochemicals
Labeling & Detection
Reactive Probes

Research Area

Application

Click Chemistry

Biotin-PEG3-azide

Item No. 23419

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aS,4S,6aR)-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
CAS Number
875770-34-6
Synonyms
  • Azide-PEG3-biotin
  • Click Tag™ Biotin-PEG3-azide
Molecular Formula
C18H32N6O5S
Formula Weight
444.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C1N[C@@]2([H])[C@@](CS[C@H]2CCCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)([H])N1
InChi Code
InChI=1S/C18H32N6O5S/c19-24-21-6-8-28-10-12-29-11-9-27-7-5-20-16(25)4-2-1-3-15-17-14(13-30-15)22-18(26)23-17/h14-15,17H,1-13H2,(H,20,25)(H2,22,23,26)/t14-,15-,17-/m0/s1
InChi Key
ZWFOOMQCYIGZBE-ZOBUZTSGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $135

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    50 mg

    $203

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    Product Description

    Biotin-PEG3-azide is a PEGylated version of biotin-azide (Item No. 13040) that is more hydrophilic due to the incorporation of a PEGylated spacer. It can be used to label terminal alkynes via copper-catalyzed click reactions or copper-free click reactions with cyclooctynes.1,2 Biotin-PEG3-azide has been used to non-enzymatically and covalently tag proteins, which can be separated and detected using common laboratory methods such as SDS-PAGE and Western blot.3 It can be used in combination with other protein tags. Biotin-PEG3-azide has also been used in nanostructured biointerfaces to study ligand and receptor spacing when there are different signaling molecules present.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schenk, F.C., Boehm, H., Spatz, J.P., et al. Dual-functionalized nanostructured bio-interfaces by click chemistry. Langmuir 30(23), 6897-6905 (2014).

    2. Nonaka, H., Tsukiji, S., Ojida, A., et al. Non-enzymatic covalent protein labeling using a reactive tag. J. Am. Chem. Soc. 129(51), 15777-15779 (2007).

    3. Lluis, M., Wang, Y., Monzingo, A.F., et al. Characterization of C-alkyl amidines as bioavailable covalent reversible inhibitors of human DDAH-1. Chem. Med. Chem. 6(1), 81-88 (2011).