A precursor used in PET imaging studies of dopamine receptor availability
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Fluoroclebopride

Item No. 23447

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-5-chloro-N-[1-[(4-fluorophenyl)methyl]-4-piperidinyl]-2-methoxy-benzamide
CAS Number
154540-49-5
Molecular Formula
C20H23ClFN3O2
Formula Weight
391.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
212, 274, 309 nm
SMILES
COC1=C(C(NC2CCN(CC3=CC=C(F)C=C3)CC2)=O)C=C(Cl)C(N)=C1
InChi Code
InChI=1S/C20H23ClFN3O2/c1-27-19-11-18(23)17(21)10-16(19)20(26)24-15-6-8-25(9-7-15)12-13-2-4-14(22)5-3-13/h2-5,10-11,15H,6-9,12,23H2,1H3,(H,24,26)
InChi Key
HKDIGEWWDHALIS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    Product Description

    Fluoroclebopride is a benzamide analog that is used in positron emission tomography (PET) applications.1,2 It binds reversibly to dopamine receptors (Kis = 0.95, 5.7, 5.46, and 144 nM for D2-like, D2(long), D3, and D4 receptors, respectively, in radioligand binding assays).3 It is selective for these receptors over D1, serotonin 5-HT2, and α2-adrenergic receptors (Kis = >10,000, 283, and 1,300 nM, respectively).4,5 A fluorine-18 moiety has been used to label this compound for use as a probe for studying D2/D3 receptor availability via PET in various monkey models.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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