(−)-Borneol

(−)-Borneol is a bicyclic monoterpene originally found in A. canadense.^1,2 It is a positive allosteric modulator of α₁β₂γ_2L subunit-containing GABA_A receptors with an EC₅₀ value of 237 µM for human recombinant receptors expressed in X. laevis oocytes.¹ It increases the latency to first pentylenetetrazole- and maximal electroshock-induced seizure in mice when administered at doses of 50, 100, and 200 mg/kg.³ (–)-Borneol (300 mg/kg) also increases the permeability of the blood-brain barrier and increases the concentration of cisplatin reaching tumors in a mouse model of glioblastoma multiforme.⁴ Formulations containing (–)-borneol have been used as fragrance ingredients.

WARNING This product is not for human or veterinary use.

1. Granger, R.E., Campbell, E.L., and Johnston, G.A.R. (+)- And (–)-borneol: Efficacious positive modulators of GABA action at human recombinant α1β₂γ2L GABA_A receptors. Biochem. Pharmacol. 69(7), 1101-1111 (2005).

2. Power, F.B., and Lees, F.H. The constituents of the essential oil of Asarum canadense. J. Chem. Soc., Trans. 81, 59-73 (1902).

3. Quintans, -.J., L.J., Guimarães, A.G., Araújo, B.E.S., et al. Carvacrol, (−)-borneol and citral reduce convulsant activity in rodents. J. Biotechnol. 9(39), 6566-6572 (2010).

4. Yin, Y., Cao, L., Ge, H., et al. L-Borneol induces transient opening of the blood-brain barrier and enhances the therapeutic effect of cisplatin. Neuroreport 28(9), 506-513 (2017).